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Kazunari Taira Selected Research

Catalytic RNA (Ribozymes)

10/2005Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
9/2004Identification of metastasis-related genes in a mouse model using a library of randomized ribozymes.
7/2004A novel maxizyme vector targeting a bcr-abl fusion gene induced specific cell death in Philadelphia chromosome-positive acute lymphoblastic leukemia.
3/2004LIM kinase-2 targeting as a possible anti-metastasis therapy.
2/2004An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease.
6/2003Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain.
6/2003Targeting mortalin using conventional and RNA-helicase-coupled hammerhead ribozymes.
5/2003Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes.
1/2003Use of a ribozyme library for validation of gene functions and cellular pathways.
1/2003Cancer gene validation using ribozymes and macroarray.
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Kazunari Taira Research Topics

Disease

27Neoplasms (Cancer)
05/2006 - 01/2002
8Neoplasm Metastasis (Metastasis)
05/2007 - 01/2002
5Melanoma (Melanoma, Malignant)
01/2006 - 01/2002
4Virus Diseases (Viral Diseases)
03/2006 - 01/2002
4Infections
01/2006 - 07/2004
3Carcinogenesis
02/2006 - 01/2005
3Carcinoma (Carcinomatosis)
12/2005 - 05/2005
3Pancreatic Neoplasms (Pancreatic Cancer)
09/2005 - 05/2004
3Neuroblastoma
01/2005 - 06/2003
3Alzheimer Disease (Alzheimer's Disease)
02/2004 - 06/2003
2Insulin Resistance
06/2006 - 06/2003
2Leukemia
05/2006 - 10/2003
2Fibrosarcoma
03/2004 - 01/2003
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
12/2005
1Glioma (Gliomas)
12/2005
1Ascites
09/2005
1Hypertrophy
03/2005
1Autoimmune Diseases (Autoimmune Disease)
01/2005
1Communicable Diseases (Infectious Diseases)
01/2005
1Parkinson Disease (Parkinson's Disease)
01/2005
1Huntington Disease (Huntington's Disease)
01/2005
1BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
07/2004
1Papilloma (Papillomatosis)
04/2004
1Genetic Translocation (Chromosomal Translocation)
10/2003
1Acute Promyelocytic Leukemia
10/2003
1Amyloid Plaque
10/2003
1Fibrosis (Cirrhosis)
09/2003
1Type 2 Diabetes Mellitus (MODY)
06/2003
1Obesity
06/2003
1Hepatitis C
06/2003

Drug/Important Bio-Agent (IBA)

14Proteins (Proteins, Gene)FDA Link
05/2007 - 01/2002
12Catalytic RNA (Ribozymes)IBA
10/2005 - 01/2002
10Small Interfering RNA (siRNA)IBA
12/2005 - 01/2002
4mortalinIBA
10/2005 - 06/2003
3Peptides (Polypeptides)IBA
05/2007 - 10/2003
3Transforming Growth Factor beta (TGF-beta)IBA
05/2005 - 05/2004
2MicroRNAs (MicroRNA)IBA
03/2006 - 01/2005
2RNA (Ribonucleic Acid)IBA
03/2006 - 01/2004
2Mitogen-Activated Protein KinasesIBA
02/2006 - 08/2004
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2005 - 07/2005
2Oncogene Proteins (Oncogene Protein)IBA
05/2005 - 10/2003
2Phosphotransferases (Kinase)IBA
02/2005 - 08/2004
2eIF-2 Kinase (eIF 2 Kinase)IBA
01/2005 - 02/2004
2IntegrinsIBA
08/2004 - 01/2002
2Telomerase (Telomerase Reverse Transcriptase)IBA
04/2004 - 08/2002
2Messenger RNA (mRNA)IBA
06/2003 - 01/2003
2Transcription Factor AP-2IBA
01/2003 - 01/2002
1AntibodiesIBA
05/2007
1Heterogeneous-Nuclear Ribonucleoprotein KIBA
05/2007
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2006
1adenovirus associated RNA (VA RNA)IBA
03/2006
1UbiquitinIBA
01/2006
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
01/2006
1Superoxide DismutaseIBA
12/2005
1CopperIBA
12/2005
1ZincIBA
12/2005
1LigandsIBA
12/2005
1Patched ReceptorsIBA
12/2005
1Cyclin-Dependent Kinases (cdk Proteins)IBA
12/2005
1Tretinoin (Retinoic Acid)FDA LinkGeneric
09/2005
1Mutant Proteins (Protein, Mutant)IBA
09/2005
1Antiviral Agents (Antivirals)IBA
09/2005
1Protein Isoforms (Isoforms)IBA
09/2005
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
09/2005
1Viral RNAIBA
09/2005
1Chemokine CXCL12IBA
07/2005
1Angiotensin IIIBA
03/2005
1DinoprostIBA
03/2005
1Platelet-Derived Growth FactorIBA
03/2005
1NADPH Oxidase 1IBA
03/2005
1NADPH Oxidases (NAD(P)H oxidase)IBA
03/2005
1I-kappa B KinaseIBA
02/2005
1NF-kappa B (NF-kB)IBA
02/2005
1Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2005
1EpitopesIBA
01/2005
1glucose-regulated proteinsIBA
01/2005
1Fibronectins (Fibronectin)IBA
12/2004
1Cytochrome P450 Family 2IBA
09/2004
1Stromal Interaction Molecule 1IBA
09/2004
1Matrix Metalloproteinases (MMPs)IBA
08/2004
1matrigelIBA
08/2004
1Tetracycline (Achromycin)FDA LinkGeneric
07/2004
1SurvivinIBA
07/2004
1EnzymesIBA
04/2004
1Lim KinasesIBA
03/2004
1TunicamycinIBA
02/2004
1Retinoic Acid Receptor alphaIBA
10/2003
1Transfer RNA (tRNA)IBA
10/2003
1Amyloid beta-PeptidesIBA
10/2003
1CollagenIBA
09/2003
1AdiponectinIBA
06/2003
1Glucose (Dextrose)FDA LinkGeneric
06/2003
1RNA Helicases (RNA Helicase)IBA
06/2003
1Cyclin-Dependent Kinase Inhibitor p16IBA
09/2002
1rhodacyanineIBA
08/2002

Therapy/Procedure

6Therapeutics
07/2004 - 01/2002
1Bone Marrow Transplantation (Transplantation, Bone Marrow)
05/2006
1Intraperitoneal Injections
09/2005
1Radiotherapy
08/2005
1Quantum Dots (Quantum Dot)
12/2003